• 靶点：
• ALDH1A2

• 简介：
• >>Retinol metabolism;>>Metabolic pathways

• 基因名称：
• ALDH1A2

• 蛋白名称：
• Retinal dehydrogenase 2

• Human Gene Id：
• 8854

• Human Swiss Prot No：
• O94788

• Mouse Gene Id：
• 19378

• Mouse Swiss Prot No：
• Q62148

• Rat Gene Id：
• 116676

• Rat Swiss Prot No：
• Q63639

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human ALDH1A2. AA range:412-461

• 特异性：
• ALDH1A2 Polyclonal Antibody detects endogenous levels of ALDH1A2 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000.IHC:1:50-300 ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• ALDH1A2;RALDH2;Retinal dehydrogenase 2;RALDH 2;RalDH2;Aldehyde dehydrogenase family 1 member A2;Retinaldehyde-specific dehydrogenase type 2;RALDH(II)

• 实测条带：
• 52kD

• 背景：
• This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2011],

• 功能：
• catalytic activity:Retinal + NAD(+) + H(2)O = retinoate + NADH.,function:Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently.,pathway:Cofactor metabolism; retinol metabolism.,similarity:Belongs to the aldehyde dehydrogenase family.,subunit:Homotetramer.,

• 细胞定位：
• Cytoplasm.

• 组织表达：
• Testis,Uterus,

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