• 靶点：
• AKR1A1

• 简介：
• >>Glycolysis / Gluconeogenesis;>>Pentose and glucuronate interconversions;>>Ascorbate and aldarate metabolism;>>Glycerolipid metabolism;>>Pyruvate metabolism;>>Metabolic pathways;>>Biosynthesis of cofactors;>>Chemical carcinogenesis - reactive oxygen species

• 基因名称：
• AKR1A1

• 蛋白名称：
• Alcohol dehydrogenase [NADP(+)]

• Human Gene Id：
• 10327

• Human Swiss Prot No：
• P14550

• Mouse Gene Id：
• 58810

• Mouse Swiss Prot No：
• Q9JII6

• Rat Gene Id：
• 78959

• Rat Swiss Prot No：
• P51635

• 免疫原：
• Synthesized peptide derived from AKR1A1 . at AA range: 250-330

• 特异性：
• AKR1A1 Polyclonal Antibody detects endogenous levels of AKR1A1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• AKR1A1;ALDR1;ALR;Alcohol dehydrogenase [NADP(+)];Aldehyde reductase;Aldo-keto reductase family 1 member A1

• 实测条带：
• 37kD

• 背景：
• This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011],

• 功能：
• catalytic activity:An alcohol + NADP(+) = an aldehyde + NADPH.,function:Catalyzes the NADPH-dependent reduction of a variety of aldehydes to their corresponding alcohols.,similarity:Belongs to the aldo/keto reductase family.,subunit:Monomer.,

• 细胞定位：
• Cytoplasm, cytosol . Apical cell membrane .

• 组织表达：
• Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung.

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