• 靶点：
• AF-4

• 简介：
• >>Transcriptional misregulation in cancer

• 基因名称：
• AFF1

• 蛋白名称：
• AF4/FMR2 family member 1

• Human Gene Id：
• 4299

• Human Swiss Prot No：
• P51825

• Mouse Swiss Prot No：
• O88573

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human AF4. AA range:1-50

• 特异性：
• AF-4 Polyclonal Antibody detects endogenous levels of AF-4 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• AFF1;AF4;FEL;MLLT2;PBM1;AF4/FMR2 family member 1;ALL1-fused gene from chromosome 4 protein;Protein AF-4;Protein FEL;Proto-oncogene AF4

• 实测条带：
• 130kD

• 背景：
• This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in mu

• 功能：
• disease:A chromosomal aberration involving AFF1 is associated with acute leukemias. Translocation t(4;11)(q21;q23) with MLL/HRX. The result is a rogue activator protein.,similarity:Belongs to the AF4 family.,

• 细胞定位：
• Nucleus .

• 组织表达：
• Epithelium,PCR rescued clones,Placenta,

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