ADAMTS-19 Polyclonal Antibody
- 货号：YT0116
- 应用：WB;ELISA
- 种属：Human;Mouse
- 蛋白名称：
- A disintegrin and metalloproteinase with thrombospondin motifs 19
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human ADAMTS19. AA range:251-300
- 特异性：
- ADAMTS-19 Polyclonal Antibody detects endogenous levels of ADAMTS-19 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- ADAMTS19;A disintegrin and metalloproteinase with thrombospondin motifs 19;ADAM-TS 19;ADAM-TS19;ADAMTS-19
- 背景：
- This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS16, another family member. [provided by RefSeq, Jul 2008],
- 功能：
- cofactor:Binds 1 zinc ion per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 peptidase M12B domain.,similarity:Contains 1 PLAC domain.,similarity:Contains 5 TSP type-1 domains.,tissue specificity:Expressed in fetal lung, but not in any adult tissues examined. Expression was detected in an osteosarcoma cDNA library.,
- 细胞定位：
- Secreted, extracellular space, extracellular matrix .
- 组织表达：
- Expressed in fetal lung, but not in any adult tissues examined. Expression was detected in an osteosarcoma cDNA library.
- Western Blot analysis of 293 cells using ADAMTS-19 Polyclonal Antibody
- Western blot analysis of the lysates from RAW264.7cells using ADAMTS19 antibody.
