ACTR-IIA Polyclonal Antibody
- 货号：YT0108
- 应用：WB;ELISA
- 种属：Human;Mouse;Rat
- 简介：
- >>Cytokine-cytokine receptor interaction;>>TGF-beta signaling pathway;>>Signaling pathways regulating pluripotency of stem cells;>>Fluid shear stress and atherosclerosis
- 蛋白名称：
- Activin receptor type-2A
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human ACTR-IIA. AA range:10-59
- 特异性：
- ACTR-IIA Polyclonal Antibody detects endogenous levels of ACTR-IIA protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- ACVR2A;ACVR2;Activin receptor type-2A;Activin receptor type IIA;ACTR-IIA;ACTRIIA
- 背景：
- This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013],
- 功能：
- catalytic activity:ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.,cofactor:Magnesium or manganese.,function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3.,
- 细胞定位：
- Membrane; Single-pass type I membrane protein.
- 组织表达：
- Mammary gland,Testis,
- Western blot analysis of lysates from rat kidney, using ACTR-IIA antibody.
