• 靶点：
• ACSL6

• 简介：
• >>Fatty acid biosynthesis;>>Fatty acid degradation;>>Metabolic pathways;>>Fatty acid metabolism;>>PPAR signaling pathway;>>Peroxisome;>>Ferroptosis;>>Thermogenesis;>>Adipocytokine signaling pathway

• 基因名称：
• ACSL6

• 蛋白名称：
• Long-chain-fatty-acid--CoA ligase 6

• Human Gene Id：
• 23305

• Human Swiss Prot No：
• Q9UKU0

• Mouse Gene Id：
• 216739

• Mouse Swiss Prot No：
• Q91WC3

• Rat Gene Id：
• 117243

• Rat Swiss Prot No：
• P33124

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human ACSL6. AA range:499-548

• 特异性：
• ACSL6 Polyclonal Antibody detects endogenous levels of ACSL6 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• ACSL6;ACS2;FACL6;KIAA0837;LACS5;Long-chain-fatty-acid--CoA ligase 6;Long-chain acyl-CoA synthetase 6;LACS 6

• 实测条带：
• 78kD

• 背景：
• The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011],

• 功能：
• catalytic activity:ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA.,cofactor:Magnesium.,developmental stage:Expression is low at earlier stages of erythroid development but is very high in reticulocytes.,disease:A chromosomal aberration involving ACSL6 may be a cause of acute eosinophilic leukemia (AEL). Translocation t(5;12)(q31;p13) with ETV6.,disease:A chromosomal aberration involving ACSL6 may be a cause of acute myelogenous leukemia with eosinophilia. Translocation t(5;12)(q31;p13) with ETV6.,disease:A chromosomal aberration involving ACSL6 may be a cause of myelodysplastic syndrome with basophilia. Translocation t(5;12)(q31;p13) with ETV6.,function:Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utiliz

• 细胞定位：
• Mitochondrion outer membrane ; Single-pass type III membrane protein . Peroxisome membrane ; Single-pass type III membrane protein . Microsome membrane ; Single-pass type III membrane protein . Endoplasmic reticulum membrane ; Single-pass type III membrane protein .

• 组织表达：
• Expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derived from fetal liver, hemopoietic stem cells from cord blood, bone marrow and brain.

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