ABCD4 Polyclonal Antibody
- 货号：YT0050
- 应用：WB;IHC;IF;ELISA
- 种属：Human;Mouse
- 简介：
- >>ABC transporters;>>Peroxisome
- 蛋白名称：
- ATP-binding cassette sub-family D member 4
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human ABCD4. AA range:111-160
- 特异性：
- ABCD4 Polyclonal Antibody detects endogenous levels of ABCD4 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- ABCD4;PXMP1L;ATP-binding cassette sub-family D member 4;PMP70-related protein;P70R;Peroxisomal membrane protein 1-like;PXMP1-L;Peroxisomal membrane protein 69;PMP69
- 背景：
- The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxi
- 功能：
- similarity:Belongs to the ABC transporter family. ALD subfamily.,similarity:Contains 1 ABC transmembrane type-1 domain.,similarity:Contains 1 ABC transporter domain.,subunit:Homodimer or heterodimer .,tissue specificity:Ubiquitous.,
- 细胞定位：
- Endoplasmic reticulum membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Targeted by LMBRD1 lysosomal chaperone to the lysosomal membrane. .
- Western Blot analysis of various cells using ABCD4 Polyclonal Antibody diluted at 1:500
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- Western Blot analysis of HepG2 cells using ABCD4 Polyclonal Antibody diluted at 1:500
- Western blot analysis of the lysates from HeLa cells using ABCD4 antibody.
- Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
