ABCC12 Polyclonal Antibody
- 货号：YT0047
- 应用：WB;ELISA
- 种属：Human;Rat;Mouse;
- 蛋白名称：
- Multidrug resistance-associated protein 9
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human MRP9. AA range:691-740
- 特异性：
- ABCC12 Polyclonal Antibody detects endogenous levels of ABCC12 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- ABCC12;MRP9;Multidrug resistance-associated protein 9;ATP-binding cassette sub-family C member 12
- 背景：
- This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer. [provided by RefSeq, Jul 2008],
- 功能：
- developmental stage:Expressed in fetal tissues.,function:Probable transporter.,similarity:Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily.,similarity:Contains 2 ABC transmembrane type-1 domains.,similarity:Contains 2 ABC transporter domains.,tissue specificity:Expressed in testis (at protein level). Widely expressed at low level. Isoform 5 is specifically expressed in brain, testis and breast cancer cells.,
- 细胞定位：
- Endoplasmic reticulum membrane ; Multi-pass membrane protein .
- 组织表达：
- Expressed in testis (at protein level). Widely expressed at low level (PubMed:11483364, PubMed:11688999, PubMed:12011458, PubMed:17472575). Isoform 5 is specifically expressed in brain, testis and breast cancer cells (PubMed:11483364, PubMed:11688999, PubMed:12011458).
- Western Blot analysis of various cells using ABCC12 Polyclonal Antibody diluted at 1:500
- Western blot analysis of lysates from 293, HepG2, and HUVEC cells, using MRP9 Antibody. The lane on the right is blocked with the synthesized peptide.
