ABCA6 Polyclonal Antibody
- 货号：YT0043
- 应用：WB;ELISA
- 种属：Human;Mouse
- 蛋白名称：
- ATP-binding cassette sub-family A member 6
- 免疫原：
- Synthesized peptide derived from ABCA6 . at AA range: 1180-1260
- 特异性：
- ABCA6 Polyclonal Antibody detects endogenous levels of ABCA6 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- ABCA6;ATP-binding cassette sub-family A member 6
- 背景：
- The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24 and may play a role in macrophage lipid homeostasis. [provided by RefSeq, Jul 2008],
- 功能：
- developmental stage:Expressed in fetal kidney, lung and liver.,function:Probable transporter which may play a role in macrophage lipid homeostasis.,induction:Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages.,similarity:Belongs to the ABC transporter family. ABCA subfamily.,similarity:Contains 2 ABC transporter domains.,tissue specificity:Widely expressed with higher expression in liver.,
- 细胞定位：
- Golgi apparatus membrane ; Multi-pass membrane protein .
- 组织表达：
- Widely expressed with higher expression in liver.
- Western Blot analysis of various cells using ABCA6 Polyclonal Antibody
