GFAP (Phospho Ser13) Rabbit pAb
- 货号：YP1820
- 应用：IHC;WB
- 种属：Human;Mouse;Rat
- 简介：
- >>JAK-STAT signaling pathway
- 蛋白名称：
- Glial fibrillary acidic protein (GFAP)
- 免疫原：
- Synthesized peptide derived from human GFAP (Phospho Ser13)
- 特异性：
- This antibody detects endogenous levels of GFAP (Phospho Ser13) Rabbit pAb at Human, Mouse,Rat
- 组成：
- Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
- 稀释：
- WB 1:500-2000 IHC 1:50-200
- 纯化工艺：
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- Glial fibrillary acidic protein (GFAP)
- 背景：
- glial fibrillary acidic protein(GFAP) Homo sapiens This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008],
- 功能：
- alternative products:Isoforms differ in the C-terminal region which is encoded by alternative exons,disease:Defects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.,function:GFAP, a class-III intermediate filament, is a cell-spe
- 细胞定位：
- Cytoplasm . Associated with intermediate filaments. .
- 组织表达：
- Expressed in cells lacking fibronectin.
- Western Blot analysis of mouse brain tissue, using primary antibody at 1:1000 dilution 4°C, overnight. Secondary antibody(catalog#:RS23920) was diluted at 1:10000 25°C，1.5hours
