NDEL1 (Phospho Thr219) rabbit pAb
- 货号：YP1792
- 应用：WB
- 种属：Human;Mouse;Rat
- 基因名称：
- NDEL1 EOPA MITAP1 NUDEL
- 蛋白名称：
- NDEL1 (Phospho-Thr219)
- 免疫原：
- Synthesized peptide derived from human NDEL1 (Phospho-Thr219)
- 特异性：
- This antibody detects endogenous levels of NDEL1 (Phospho-Thr219) at Human, Mouse,Rat
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 纯化工艺：
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1)
- 背景：
- This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Mar 2012],
- 功能：
- caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,caution:Was originally (PubMed:15728732) thought to function as an oligopeptidase (NUDEL-oligopeptidase or endooligopeptidase A) which could regulate peptide levels relevant to brain function.,developmental stage:Expression peaks in mitosis.,function:Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL (By similarity). Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the m
- 细胞定位：
- Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the microtubules of the manchette in elongated spermatids. Colocalizes with DISC1 in the perinuclear region, including the centrosome (By similarity). Localizes to the interphase centrosome and the mitotic spindle. Localizes to the kinetochore in a CENPF-dependent manner. .
- 组织表达：
- Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.
- Western Blot analysis of 1 HepG2 cell 2, LPS 100ng/mL 30min treated ,using primary antibody at 1:1000 dilution. Secondary antibody(catalog#:RS23920) was diluted at 1:10000
