• 靶点：
• STF-1

• 简介：
• >>Cortisol synthesis and secretion;>>Cushing syndrome

• 基因名称：
• NR5A1 AD4BP FTZF1 SF1

• 蛋白名称：
• STF-1 (Phospho-Ser203)

• Human Gene Id：
• 2516

• Human Swiss Prot No：
• Q13285

• Mouse Gene Id：
• 26423

• Mouse Swiss Prot No：
• P33242

• Rat Gene Id：
• 83826

• Rat Swiss Prot No：
• P50569

• 免疫原：
• Synthesized peptide derived from human STF-1 (Phospho-Ser203)

• 特异性：
• This antibody detects endogenous levels of STF-1 (Phospho-Ser203) at Human, Mouse,Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Steroidogenic factor 1 (SF-1) (STF-1) (Adrenal 4-binding protein) (Fushi tarazu factor homolog 1) (Nuclear receptor subfamily 5 group A member 1) (Steroid hormone receptor Ad4BP)

• 分子量：
• 51kD

• 背景：
• The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. [provided by RefSeq, Jul 2008],

• 功能：
• disease:Defects in NR5A1 are a cause of adrenocortical insufficiency without ovarian defect [MIM:184757]. The disease is characterized by severe 'slackness,' muscular hypotonia. There is decreased sodium, increased potassium and elevated ACTH.,disease:Defects in NR5A1 are a cause of XY sex reversal with or without adrenal failure [MIM:184757]. This disease is characterized by normal female external genitalia and retention of the uterus.,function:Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P-450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the Muellerian inhibiting substance (AMH) gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1/FTZF1. The SFPQ-NO

• 细胞定位：
• Nucleus .

• 组织表达：
• High expressed in the adrenal cortex, the ovary, the testis, and the spleen (PubMed:9177385).

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