• 靶点：
• PASK

• 基因名称：
• PASK KIAA0135

• 蛋白名称：
• PASK (Phospho-Thr1165)

• Human Gene Id：
• 23178

• Human Swiss Prot No：
• Q96RG2

• Mouse Gene Id：
• 269224

• Mouse Swiss Prot No：
• Q8CEE6

• 免疫原：
• Synthesized peptide derived from human PASK (Phospho-Thr1165)

• 特异性：
• This antibody detects endogenous levels of PASK (Phospho-Thr1165) at Human, Mouse,Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1)

• 分子量：
• 146kD

• 背景：
• This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011],

• 功能：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Activated by autophosphorylation on Thr-1161 and Thr-1165 and inhibited by the first PAS domain.,PTM:Autophosphorylated on Thr-1161 and Thr-1165.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 PAS (PER-ARNT-SIM) domains.,tissue specificity:Ubiquitously expressed, with slightly higher expression in brain, prostate and testis. Reduced expression was found in placenta.,

• 细胞定位：
• Cytoplasm . Nucleus . Localizes in the nucleus of testis germ cells and in the midpiece of sperm tails.

• 组织表达：
• Ubiquitously expressed, with slightly higher expression in brain, prostate and testis. Reduced expression was found in placenta. Present in germ cells of testis and in the midpiece of sperm tails (at protein level).

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