• 靶点：
• PDE3A

• 简介：
• >>Purine metabolism;>>Metabolic pathways;>>cGMP-PKG signaling pathway;>>cAMP signaling pathway;>>Renin secretion;>>Morphine addiction

• 基因名称：
• PDE3A

• 蛋白名称：
• PDE3A (Phospho-Ser312)

• Human Gene Id：
• 5139

• Human Swiss Prot No：
• Q14432

• Mouse Gene Id：
• 54611

• Mouse Swiss Prot No：
• Q9Z0X4

• Rat Gene Id：
• 50678

• Rat Swiss Prot No：
• Q62865

• 免疫原：
• Synthesized peptide derived from human PDE3A (Phospho-Ser312)

• 特异性：
• This antibody detects endogenous levels of PDE3A (Phospho-Ser312) at Human, Mouse,Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A)

• 分子量：
• 126kD

• 背景：
• This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011],

• 功能：
• catalytic activity:Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.,enzyme regulation:Inhibited by cGMP.,function:Hydrolyzes both cyclic AMP (cAMP) and cyclic GMP (cGMP).,online information:PDE3 entry,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,

• 细胞定位：
• Membrane ; Multi-pass membrane protein . Cytoplasm, cytosol .

• 组织表达：
• Blood,Epithelium,Liver,Myocardium,Penis,Platelet,

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