BLK (Phospho Tyr389) rabbit pAb
- 货号：YP1695
- 应用：WB
- 种属：Human;Mouse;Rat
- 蛋白名称：
- BLK (Phospho-Tyr389)
- 免疫原：
- Synthesized peptide derived from human BLK (Phospho-Tyr389)
- 特异性：
- This antibody detects endogenous levels of BLK (Phospho-Tyr389) at Human, Mouse,Rat
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 纯化工艺：
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk)
- 背景：
- This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010],
- 功能：
- catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:May function in a signal transduction pathway that is restricted to B-lymphoid cells.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,
- 细胞定位：
- Cell membrane ; Lipid-anchor . Present and active in lipid rafts. Membrane location is required for the phosphorylation of CD79A and CD79B (By similarity). .
- 组织表达：
- Expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles.
