• 靶点：
• QIK/QSK

• 简介：
• >>Glucagon signaling pathway

• 基因名称：
• SIK1 SIK SNF1LK

• 蛋白名称：
• SIK (Phospho-Thr182)

• Human Gene Id：
• 150094

• Human Swiss Prot No：
• P57059

• Mouse Gene Id：
• 17691

• Mouse Swiss Prot No：
• Q60670

• Rat Gene Id：
• 59329

• Rat Swiss Prot No：
• Q9R1U5

• 免疫原：
• Synthesized peptide derived from human SIK (Phospho-Thr182)

• 特异性：
• This antibody detects endogenous levels of SIK (Phospho-Thr182) at Human, Mouse,Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Serine/threonine-protein kinase SIK1 (EC 2.7.11.1) (Salt-inducible kinase 1) (SIK-1) (Serine/threonine-protein kinase SNF1-like kinase 1) (Serine/threonine-protein kinase SNF1LK)

• 分子量：
• 86kD

• 功能：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-182 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,function:Transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. Potential role in G2/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 UBA domain.,subcellular location:Translocates to the cytoplasm on phosp

• 细胞定位：
• Cytoplasm . Nucleus . Locates to cytoplasm when inactive following cAMP-induced phosphorylation, probably by PKA (PubMed:29211348).

• 组织表达：
• Fetal lung,Spleen,Testis,

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• WESTERN IMMUNOBLOTTING PROTOCOL

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• July 13-2018
• CELL-BASED-ELISA-PROTOCOL-FOR-ACETYL-PROTEIN

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