• 靶点：
• PDK1

• 简介：
• >>HIF-1 signaling pathway;>>Central carbon metabolism in cancer

• 基因名称：
• PDK1 PDHK1

• 蛋白名称：
• PDHK1 (Phospho Thr338)

• Human Gene Id：
• 5163

• Human Swiss Prot No：
• Q15118

• Mouse Gene Id：
• 228026

• Mouse Swiss Prot No：
• Q8BFP9

• Rat Swiss Prot No：
• Q63065

• 免疫原：
• Synthesized peptide derived from human PDHK1 (Phospho Thr338)

• 特异性：
• This antibody detects endogenous levels of Human,Mouse,Rat PDHK1 (Phospho Thr338)

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial (EC 2.7.11.2;Pyruvate dehydrogenase kinase isoform 1)

• 实测条带：
• 50kD

• 背景：
• Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013],

• 功能：
• catalytic activity:ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.,function:Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.,similarity:Belongs to the PDK/BCKDK protein kinase family.,similarity:Contains 1 histidine kinase domain.,tissue specificity:Expressed predominantly in the heart.,

• 细胞定位：
• Mitochondrion matrix .

• 组织表达：
• Expressed predominantly in the heart. Detected at lower levels in liver, skeletal muscle and pancreas.

Elucidation of the anti-gastric cancer mechanism of Guiqi Baizhu Formula by integrative approach of chemical bioinformatics INTERNATIONAL IMMUNOPHARMACOLOGY Yanru Wang WB Human MKN-45 cell
货号：YP1634

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