TPOR (phospho-Tyr626) rabbit pAb

  • 货号:YP1535
  • 应用:WB
  • 种属:Human
    • 基因名称:
    • MPL TPOR
    • 蛋白名称:
    • TPOR (Tyr626)
    • Human Gene Id:
    • 4352
    • Human Swiss Prot No:
    • P40238
    • Mouse Swiss Prot No:
    • Q08351
    • 免疫原:
    • Synthesized phosho peptide around human TPOR (Tyr626)
    • 特异性:
    • This antibody detects endogenous levels of Human TPOR (phospho-Tyr626)
    • 组成:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • 来源:
    • Rabbit
    • 稀释:
    • WB 1:1000-2000
    • 纯化工艺:
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • 浓度:
    • 1 mg/ml
    • 储存:
    • -20°C/1 year
    • 其他名称:
    • Thrombopoietin receptor (TPO-R) (Myeloproliferative leukemia protein) (Proto-oncogene c-Mpl) (CD antigen CD110)
    • 实测条带:
    • 69,40
    • 背景:
    • MPL proto-oncogene, thrombopoietin receptor(MPL) Homo sapiens In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important
    • 功能:
    • caution:It is uncertain whether Met-1 or Met-8 is the initiator.,disease:Defects in MPL are a cause of congenital amegakaryocytic thrombocytopenia (CAMT) [MIM:604498]. CAMT is a disease characterized by isolated thrombocytopenia and megakaryocytopenia with no physical anomalies.,domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses.,similarity:Belongs to the type I cytokine receptor family. Type 1 subfamily.,similarity:Contains 2 fibronectin type-III domains.,subunit:Interacts with ATXN2L.,tissue specificity:Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and
    • 细胞定位:
    • Golgi apparatus,plasma membrane,integral component of plasma membrane,cell surface,integral component of membrane,neuron projection,neuronal cell body,