TAZ (Phospho Ser89) rabbit pAb
- 货号：YP1526
- 应用：WB
- 种属：Human;Mouse;Rat
- 简介：
- >>Hippo signaling pathway;>>Hippo signaling pathway - multiple species
- 免疫原：
- Synthesized phosho peptide around human TAZ (Ser89)
- 特异性：
- This antibody detects endogenous levels of Human Mouse Rat TAZ (phospho-Ser89)
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 纯化工艺：
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
- 功能：
- domain:Binds to transcription factors via its WW domain.,domain:The PDZ-binding motif is essential for stimulated gene transcription. It localizes the protein into both punctate nuclear foci and plasma membrane-associated complexes.,function:Functions as a transcriptional coactivator.,PTM:Phosphorylated. Phosphorylation results in the inhibition of transcriptional coactivation through YWHAZ-mediated nuclear export.,similarity:Contains 1 WW domain.,subcellular location:Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ.,subunit:Binds to SLC9A3R2 via the PDZ motif at the plasma membrane. Binds to YWHAZ in vivo and in vitro through the phosphoserine-binding motif RSHSSP.,tissue specificity:Highly expressed in kidney, heart, placenta and lung.,
- 细胞定位：
- Nucleus . Cytoplasm . Cell membrane . Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies (By similarity). When phosphorylated, is retained in the cytoplasm by YWHAZ (By similarity). Can be retained in the nucleus by MED15 (PubMed:18568018). Localized in the cytoplasm in areas of epithelial cell high density (PubMed:21145499). At blastocyst stage expressed in the nucleus in trophectodermal cells, however expressed in the cytoplasm in the inner cell mass (By similarity). .
- 组织表达：
- Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue.
- Western blot analysis of lysates from U2OS cells, primary antibody was diluted at 1:1000, 4°over night
