• 靶点：
• Prdx1

• 简介：
• >>Peroxisome;>>Amoebiasis

• 基因名称：
• PRDX1 PAGA PAGB TDPX2

• 蛋白名称：
• Prdx1 (Tyr194) ,Peroxiredoxin-1

• Human Gene Id：
• 5052

• Human Swiss Prot No：
• Q06830

• Mouse Gene Id：
• 18477

• Mouse Swiss Prot No：
• P35700

• Rat Gene Id：
• 117254

• Rat Swiss Prot No：
• Q63716

• 免疫原：
• Synthesized phosho peptide around human Prdx1 (Tyr194)

• 特异性：
• This antibody detects endogenous levels of Human Prdx1 (phospho-Tyr194)

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Peroxiredoxin-1 (EC 1.11.1.15) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2)

• 实测条带：
• 21kD

• 背景：
• This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011],

• 功能：
• catalytic activity:2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.,function:Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).,induction:Constitutively expressed in most human cells; is induced to higher levels upon serum stimulation in untransformed and transformed cells.,miscellaneous:Inactivated upon oxidative stress by overoxidation of Cys-52 to Cys-SO(2)H and Cys-SO(3)H. Cys-SO(2)H is retroreduced to Cys-SOH after removal of H(2)O(2), while Cys-SO(3)H may be irreversibly oxidized.,miscellaneous:The active site is the redox-active Cys-52 oxidized to Cys-SOH.

• 细胞定位：
• Cytoplasm . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

• 组织表达：
• Brain,Cajal-Retzius cell,Fetal brain cortex,Urinary bladder,

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