MARCKS (Phospho Ser167/170) rabbit pAb
- 货号：YP1393
- 应用：WB
- 种属：Human;Mouse;Rat
- 简介：
- >>Fc gamma R-mediated phagocytosis;>>MicroRNAs in cancer
- 蛋白名称：
- MARCKS (Ser167/170)
- 免疫原：
- Synthesized phosho peptide around human MARCKS (Ser167 and 170)
- 特异性：
- This antibody detects endogenous levels of Human Mouse Rat MARCKS (phospho-Ser167 or 170)
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 纯化工艺：
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL)
- 背景：
- The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008],
- 功能：
- function:MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.,PTM:Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity.,similarity:Belongs to the MARCKS family.,
- 细胞定位：
- Cytoplasm, cytoskeleton . Membrane ; Lipid-anchor .
- 组织表达：
- Blood,Brain,Epithelium,Muscle,Skin,
- Western blot analysis of lysates from KB cells, primary antibody was diluted at 1:1000, 4°over night
