FoxM1 (Phospho Ser35) rabbit pAb
- 货号:YP1336
- 应用:WB
- 种属:Human;Rat;Mouse;
- 简介:
- >>Cellular senescence
- 基因名称:
- FOXM1 FKHL16 HFH11 MPP2 WIN
- 免疫原:
- Synthesized phosho peptide around human FoxM1 (Ser35)
- 特异性:
- This antibody detects endogenous levels of Human FoxM1 (phospho-Ser35)
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 纯化工艺:
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells)
- 背景:
- The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011],
- 功能:
- alternative products:Isoform 1 and isoform 2 appear to be the only activators of gene transcription. Isoform 3, found in rat, does not seem to exist in human,developmental stage:Embryonic expression pattern: liver, lung, intestine, kidney, urinary tract; adult expression pattern: intestine, colon, testis and thymus.,domain:Within the protein there is a domain which acts as a transcriptional activator. Insertion of a splicing sequence within it inactivates this transcriptional activity, as it is the case for isoform 4.,function:Transcriptional activatory factor. May play a role in the control of cell proliferation.,induction:Induced during liver regeneration and oxidative stress.,PTM:Phosphorylated in M (mitotic) phase.,similarity:Contains 1 fork-head DNA-binding domain.,tissue specificity:Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only
- 组织表达:
- Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in testis.
![](/uploadfiles/PIC/YP1336-wb-2021.jpg)
- Western Blot analysis of Hela cell lysis treated or untreated by EGF 20ng/ml 30'.. Primary Antibody was diluted at 1:1000. Secondary antibody(catalog#:RS23920 was diluted at 1:10000