CaMK2 (Phospho-Thr286) Antibody

    • 货号:YP1249
    • 应用:WB, ELISA
    • 种属:Human, Mouse, Rat
      • 基因名称:
      • CAMK2D CAMKD
      • 蛋白名称:
      • CaMK2 (Phospho-Thr286)
      • Human Gene Id:
      • 817
      • 免疫原:
      • Synthesized pospho peptide derived from human CaMK2 (Phospho-Thr286)
      • 特异性:
      • This antibody detects endogenous pospho levels of human CaMK2 (Phospho-Thr286)
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Rabbit
      • 稀释:
      • WB 1:500-2000, ELISA(peptide)1:5000-20000
      • 纯化工艺:
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -20°C/1 year
      • 其他名称:
      • Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17)
      • 实测条带:
      • 54
      • 背景:
      • calcium/calmodulin dependent protein kinase II alpha(CAMK2A) Homo sapiens The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008],
      • 功能:
      • catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state.,function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Postsynaptic lipid rafts.,subunit:CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric
      • 细胞定位:
      • nucleus,nucleoplasm,mitochondrion,cytosol,plasma membrane,postsynaptic density,cell junction,endocytic vesicle membrane,presynaptic membrane,
      • 组织表达:
      • Brain,
      • 产品图片
      • Western blot analysis of various lysates, primary antibody was diluted at 1:1000, 4° over night, secondary antibody(cat: RS23920)was diluted at 1:10000, 37° 1hour.