MER/TYRO3 (Phospho Tyr753/Tyr685) Polyclonal Antibody
- 货号：YP1208
- 应用：WB;ELISA;IHC
- 种属：Human:Y753/Y685;Mouse:Y748/Y675;Rat:Y748/Y675
- 靶点：
- MerTK/Tyro3
- 基因名称：
- MERTK MER
- 蛋白名称：
- c-mer proto-oncogene tyrosine kinase
- Human Gene Id：
- 10461/7301
- Human Swiss Prot No：
- Q12866/Q06418
- 免疫原：
- Synthesized phospho-peptide around the phosphorylation site of human MER/TYRO3 (Phospho-Tyr753/Tyr685)
- 特异性：
- This antibody detects endogenous levels of MER/TYRO3 at Human:Y753/Y685;Mouse:Y748/Y675;Rat:Y748/Y675, It doesn't reacte with total protein.
- 组成：
- PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000
- 纯化工艺：
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- 浓度：
- 1 mg/ml
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- MERTK MER
- 实测条带：
- 110kD
- 背景：
- This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008],
- 功能：
- catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in MERTK are a cause of retinitis pigmentosa (RP) [MIM:268000]. RP that leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.,function:In case of filovirus infection, seems to function as a cell entry factor.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 fibronectin type-III domains.,similarity:Contains 2 Ig-like C2-type (imm
- 细胞定位：
- Cell membrane ; Single-pass type I membrane protein .
- 组织表达：
- Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver.
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- Antibody-FAQs
- 产品图片
- Western Blot analysis of 293T cells using Antibody diluted at 500. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
- Immunohistochemical analysis of paraffin-embedded human lung cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
