• 靶点：
• Fos B

• 简介：
• >>Osteoclast differentiation;>>IL-17 signaling pathway;>>Cocaine addiction;>>Amphetamine addiction;>>Alcoholism

• 基因名称：
• FOSB

• 蛋白名称：
• Protein fosB

• Human Gene Id：
• 2354

• Human Swiss Prot No：
• P53539

• Mouse Gene Id：
• 14282

• Mouse Swiss Prot No：
• P13346

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human FosB around the phosphorylation site of Ser27. AA range:12-61

• 特异性：
• Phospho-Fos B (S27) Polyclonal Antibody detects endogenous levels of Fos B protein only when phosphorylated at S27.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• FOSB;G0S3;Protein fosB;G0/G1 switch regulatory protein 3

• 实测条带：
• 35kD

• 背景：
• The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

• 功能：
• function:FosB interacts with Jun proteins enhancing their DNA binding activity.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. Fos subfamily.,similarity:Contains 1 bZIP domain.,subunit:Heterodimer.,

• 细胞定位：
• Nucleus .

• 组织表达：
• [Isoform 11]: Expressed in the nucleus accumbens of the striatum (at protein level).

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