• 靶点：
• EphA3/4/5

• 简介：
• >>Axon guidance

• 基因名称：
• EPHA3/EPHA4/EPHA5

• 蛋白名称：
• Ephrin type-A receptor 3/4/5

• Human Gene Id：
• 2042/2043

• Human Swiss Prot No：
• P29320/P54764/P54756

• Mouse Gene Id：
• 13838/13839

• Rat Gene Id：
• 29210/79208

• Rat Swiss Prot No：
• O08680/P54757

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human EPHA3/4/5 around the phosphorylation site of Tyr779/833. AA range:746-795

• 特异性：
• Phospho-EphA3/4/5 (Y779/833) Polyclonal Antibody detects endogenous levels of EphA3/4/5 protein only when phosphorylated at Y779/833.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• EPHA3;ETK;ETK1;HEK;TYRO4;Ephrin type-A receptor 3;EPH-like kinase 4;EK4;hEK4;HEK;Human embryo kinase;Tyrosine-protein kinase TYRO4;Tyrosine-protein kinase receptor ETK1;Eph-like tyrosine kinase 1;EPHA4;HEK8;SEK;TYRO1;Ephri

• 实测条带：
• 110kD

• 背景：
• This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in EPHA3 may be a cause of colorectal cancer (CRC) [MIM:114500].,function:Receptor for members of the ephrin-A family. Binds to ephrin-A2, -A3, -A4 and -A5. Could play a role in lymphoid function.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,tissue specificity:Widely expressed. Highest level in placenta.,

• 细胞定位：
• [Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .

• 组织表达：
• Widely expressed. Highest level in placenta.

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