• 靶点：
• Gab2

• 简介：
• >>Ras signaling pathway;>>Sphingolipid signaling pathway;>>Phospholipase D signaling pathway;>>Osteoclast differentiation;>>Fc epsilon RI signaling pathway;>>Fc gamma R-mediated phagocytosis;>>Chronic myeloid leukemia

• 基因名称：
• GAB2

• 蛋白名称：
• GRB2-associated-binding protein 2

• Human Gene Id：
• 9846

• Human Swiss Prot No：
• Q9UQC2

• Mouse Swiss Prot No：
• Q9Z1S8

• Rat Gene Id：
• 84477

• Rat Swiss Prot No：
• Q9EQH1

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Gab2 around the phosphorylation site of Ser623. AA range:589-638

• 特异性：
• Phospho-Gab 2 (S623) Polyclonal Antibody detects endogenous levels of Gab 2 protein only when phosphorylated at S623.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• GAB2;KIAA0571;GRB2-associated-binding protein 2;GRB2-associated binder 2;Growth factor receptor bound protein 2-associated protein 2;pp100

• 实测条带：
• 80kD

• 背景：
• GRB2 associated binding protein 2(GAB2) Homo sapiens This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009],

• 功能：
• PTM:Dephosphorylated by PTPN11.,PTM:Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R.,similarity:Belongs to the GAB family.,similarity:Contains 1 PH domain.,subunit:Interacts with GRB2, PI-3 kinase and with other SH2-containing proteins.,

• 细胞定位：
• Cytoplasm . Cell membrane .

• 组织表达：
• Brain,Clones donated by Kazusa DNA Research Inst.,

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