• 靶点：
• CtBP1

• 简介：
• >>Wnt signaling pathway;>>Notch signaling pathway;>>Pathways in cancer;>>Chronic myeloid leukemia

• 基因名称：
• CTBP1

• 蛋白名称：
• C-terminal-binding protein 1

• Human Gene Id：
• 1487

• Human Swiss Prot No：
• Q13363

• Mouse Gene Id：
• 13016

• Mouse Swiss Prot No：
• O88712

• Rat Gene Id：
• 29382

• Rat Swiss Prot No：
• Q9Z2F5

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human CtBP1 around the phosphorylation site of Ser422. AA range:388-437

• 特异性：
• Phospho-CtBP1 (S422) Polyclonal Antibody detects endogenous levels of CtBP1 protein only when phosphorylated at S422.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CTBP1;CTBP;C-terminal-binding protein 1;CtBP1

• 实测条带：
• 48kD

• 背景：
• This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008],

• 功能：
• cofactor:NAD. Required for efficient interaction with E1A. Cofactor binding induces a conformation change.,function:Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex (By similarity). Co-repressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity.,PTM:ADP-ribosylated; when cells are exposed to brefeldin-A (BFA).,PTM:Sumoylation on Lys-428 is promoted by the E3 SUMO-protein ligase CBX4.,PTM:The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation.,similarity:Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.,subunit:Interacts with the C-terminus of adenovirus E1A protein, ELK3 and CTIP via their consensus motif P-X-[DNS]-L-[STVA]. Can form homodime

• 细胞定位：
• Cytoplasm . Nucleus .

• 组织表达：
• Expressed in germinal center B-cells.

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