• 靶点：
• MerTK/Tyro3

• 基因名称：
• MERTK/TYRO3

• 蛋白名称：
• Tyrosine-protein kinase Mer/Tyrosine-protein kinase receptor TYRO3

• Human Gene Id：
• 10461/7301

• Human Swiss Prot No：
• Q12866/Q06418

• Mouse Gene Id：
• 17289/22174

• Rat Gene Id：
• 65037/25232

• Rat Swiss Prot No：
• P57097/P55146

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human MER/SKY around the phosphorylation site of Tyr749/681. AA range:716-765

• 特异性：
• Phospho-MerTK/Tyro3 (Y749/681) Polyclonal Antibody detects endogenous levels of MerTK/Tyro3 protein only when phosphorylated at Y749/681.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• MERTK;MER;Tyrosine-protein kinase Mer;Proto-oncogene c-Mer;Receptor tyrosine kinase MerTK;TYRO3;BYK;DTK;RSE;SKY;Tyrosine-protein kinase receptor TYRO3;Tyrosine-protein kinase DTK;Tyrosine-protein kinase RSE;Tyrosine-protein kin

• 实测条带：
• 97kD

• 背景：
• This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in MERTK are a cause of retinitis pigmentosa (RP) [MIM:268000]. RP that leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.,function:In case of filovirus infection, seems to function as a cell entry factor.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 fibronectin type-III domains.,similarity:Contains 2 Ig-like C2-type (imm

• 细胞定位：
• Cell membrane ; Single-pass type I membrane protein .

• 组织表达：
• Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver.

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