• 靶点：
• PDE4B/C/D

• 简介：
• >>Purine metabolism;>>Metabolic pathways;>>cAMP signaling pathway;>>Parathyroid hormone synthesis, secretion and action;>>Morphine addiction

• 基因名称：
• PDE4B/PDE4C/PDE4D

• 蛋白名称：
• cAMP-specific 3',5'-cyclic phosphodiesterase 4D

• Human Gene Id：
• 5144

• Human Swiss Prot No：
• Q07343/Q08493/Q08499

• Mouse Gene Id：
• 110385/238871

• Rat Gene Id：
• 24626/24627

• Rat Swiss Prot No：
• P14646/P14644/P14270

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human PDE4D around the phosphorylation site of Ser190/53. AA range:156-205

• 特异性：
• Phospho-PDE4B/C/D (S133/119/190) Polyclonal Antibody detects endogenous levels of PDE4B/C/D protein only when phosphorylated at S133/119/190.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• PDE4B;DPDE4;cAMP-specific 3';5'-cyclic phosphodiesterase 4B;DPDE4;PDE32;PDE4C;DPDE1;cAMP-specific 3',5'-cyclic phosphodiesterase 4C;DPDE1;PDE21;PDE4D;DPDE3;cAMP-specific 3',5'-cyclic phosphodiesterase 4D;DPDE3;PDE43

• 实测条带：
• 76kD

• 背景：
• This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014],

• 功能：
• alternative products:Additional isoforms seem to exist,catalytic activity:Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.,enzyme regulation:Inhibited by rolipram.,function:May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.,pathway:Purine metabolism; cAMP degradation; AMP from cAMP: step 1/1.,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,tissue specificity:Expressed in brain, heart, lung and skeletal muscle.,

• 细胞定位：
• [Isoform PDE4B5]: Cytoplasm . Cell membrane .

• 组织表达：
• Expressed in brain, heart, lung and skeletal muscle (PubMed:17519386). Expressed in white blood cells (PubMed:8392015). ; [Isoform PDE4B5]: Brain-specific isoform.

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