• 靶点：
• Cdc6

• 简介：
• >>Cell cycle;>>Chemical carcinogenesis - receptor activation

• 基因名称：
• CDC6

• 蛋白名称：
• Cell division control protein 6 homolog

• Human Gene Id：
• 990

• Human Swiss Prot No：
• Q99741

• Mouse Gene Id：
• 23834

• Mouse Swiss Prot No：
• O89033

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human CDC6 around the phosphorylation site of Ser54. AA range:20-69

• 特异性：
• Phospho-Cdc6 (S54) Polyclonal Antibody detects endogenous levels of Cdc6 protein only when phosphorylated at S54.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CDC6;CDC18L;Cell division control protein 6 homolog;CDC6-related protein;Cdc18-related protein;HsCdc18;p62(cdc6);HsCDC6

• 实测条带：
• 62kD

• 背景：
• The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008],

• 功能：
• function:Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.,similarity:Belongs to the CDC6/cdc18 family.,subcellular location:The protein is nuclear in G1 and cytoplasmic in S-phase cells.,subunit:Interacts with PCNA, ORC1L, cyclin-CDK and HUWE1.,

• 细胞定位：
• Nucleus . Cytoplasm . The protein is nuclear in G1 and cytoplasmic in S-phase cells (PubMed:9566895). .

• 组织表达：
• Brain,Epithelium,

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