• 靶点：
• FoxL2

• 基因名称：
• FOXL2

• 蛋白名称：
• Forkhead box protein L2

• Human Gene Id：
• 668

• Human Swiss Prot No：
• P58012

• Mouse Gene Id：
• 26927

• Mouse Swiss Prot No：
• O88470

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human FOXL2 around the phosphorylation site of Ser263. AA range:229-278

• 特异性：
• Phospho-FoxL2 (S263) Polyclonal Antibody detects endogenous levels of FoxL2 protein only when phosphorylated at S263.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• FOXL2;Forkhead box protein L2

• 实测条带：
• 40kD

• 背景：
• This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Expansion of a polyalanine repeat region and other mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3. [provided by RefSeq, Jul 2016],

• 功能：
• disease:Defects in FOXL2 are a cause of blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES) [MIM:110100]; also known as blepharophimosis syndrome. It is an autosomal dominant disorder characterized by eyelid dysplasia, small palpebral fissures, drooping eyelids and a skin fold running inward and upward from the lower lid. In type I BPSE (BPES1) eyelid abnormalities are associated with female infertility. Affected females show an ovarian deficit due to primary amenorrhea or to premature ovarian failure (POF). In type II BPSE (BPES2) affected individuals show only the eyelid defects. There is a mutational hotspot in the region coding for the poly-Ala domain, since 30% of all mutations in the ORF lead to poly-Ala expansions, resulting mainly in BPES type II.,disease:Defects in FOXL2 are a cause of premature ovarian failure 3 (POF3) [MIM:608996]. Premature ovarian failure (POF)

• 细胞定位：
• Nucleus .

• 组织表达：
• In addition to its expression in the developing eyelid, it is transcribed very early in somatic cells of the developing gonad (before sex determination) and its expression persists in the follicular cells of the adult ovary.

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