• 靶点：
• CD28

• 简介：
• >>Cell adhesion molecules;>>T cell receptor signaling pathway;>>Intestinal immune network for IgA production;>>Type I diabetes mellitus;>>Measles;>>PD-L1 expression and PD-1 checkpoint pathway in cancer;>>Autoimmune thyroid disease;>>Systemic lupus erythematosus;>>Rheumatoid arthritis;>>Allograft rejection;>>Graft-versus-host disease;>>Viral myocarditis

• 基因名称：
• CD28

• 蛋白名称：
• T-cell-specific surface glycoprotein CD28

• Human Gene Id：
• 940

• Human Swiss Prot No：
• P10747

• Mouse Gene Id：
• 12487

• Mouse Swiss Prot No：
• P31041

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human CD28 around the phosphorylation site of Tyr218. AA range:171-220

• 特异性：
• Phospho-CD28 (Y218) Polyclonal Antibody detects endogenous levels of CD28 protein only when phosphorylated at Y218.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CD28;T-cell-specific surface glycoprotein CD28;TP44;CD antigen CD28

• 实测条带：
• 45kD

• 背景：
• The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011],

• 功能：
• function:Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.,online information:CD28 entry,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70.,tissue specificity:Expressed in T-cells and plasma cells, but not in less mature B-cells.,

• 细胞定位：
• Membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell surface .

• 组织表达：
• Expressed in T-cells and plasma cells, but not in less mature B-cells.

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