• 靶点：
• eIF4B

• 简介：
• >>mTOR signaling pathway;>>PI3K-Akt signaling pathway;>>Proteoglycans in cancer

• 基因名称：
• EIF4B

• 蛋白名称：
• Eukaryotic translation initiation factor 4B

• Human Gene Id：
• 3716

• Human Swiss Prot No：
• P23588

• Mouse Gene Id：
• 75705

• Mouse Swiss Prot No：
• Q8BGD9

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human eIF4B around the phosphorylation site of Ser422. AA range:388-437

• 特异性：
• Phospho-eIF4B (S422) Polyclonal Antibody detects endogenous levels of eIF4B protein only when phosphorylated at S422.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• EIF4B;Eukaryotic translation initiation factor 4B;eIF-4B

• 实测条带：
• 80kD

• 背景：
• function:Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Self-associates and interacts with EIF3 p170 subunit.,

• 功能：
• function:Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Self-associates and interacts with EIF3 p170 subunit.,

• 细胞定位：
• cytosol,polysome,eukaryotic translation initiation factor 4F complex,dendrite,neuronal cell body,

• 组织表达：
• Adipose tissue,Brain,Cervix carcinoma,Epithelium,Liver,Lung

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