• 靶点：
• GSK3α

• 简介：
• >>Chemokine signaling pathway;>>Dopaminergic synapse;>>Non-alcoholic fatty liver disease;>>Shigellosis

• 基因名称：
• GSK3A

• 蛋白名称：
• Glycogen synthase kinase-3 alpha

• Human Gene Id：
• 2931

• Human Swiss Prot No：
• P49840

• Mouse Gene Id：
• 606496

• Mouse Swiss Prot No：
• Q2NL51

• Rat Gene Id：
• 50686

• Rat Swiss Prot No：
• P18265

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human GSK3 alpha around the phosphorylation site of Ser21. AA range:10-59

• 特异性：
• Phospho-GSK3α (S21) Polyclonal Antibody detects endogenous levels of GSK3α protein only when phosphorylated at S21.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. Immunoprecipitation: 2-5 ug:mg lysate. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• GSK3A;Glycogen synthase kinase-3 alpha;GSK-3 alpha;Serine/threonine-protein kinase GSK3A

• 实测条带：
• 55kD

• 背景：
• glycogen synthase kinase 3 alpha(GSK3A) Homo sapiens This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011],

• 功能：
• catalytic activity:ATP + [tau protein] = ADP + [tau protein] phosphate.,function:Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer.,

• 细胞定位：
• apical dendrite;axon;beta-catenin destruction complex;cytoplasm;cytosol;mitochondrion;neuronal cell body;nucleus;postsynapse;proximal dendrite;

• 组织表达：
• Brain,Eye,Foreskin,Lung,Pancreas,Platelet,Testis,

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