• 靶点：
• DARPP-32

• 简介：
• >>cAMP signaling pathway;>>Dopaminergic synapse;>>Cocaine addiction;>>Amphetamine addiction;>>Alcoholism

• 基因名称：
• PPP1R1B

• 蛋白名称：
• Protein phosphatase 1 regulatory subunit 1B

• Human Gene Id：
• 84152

• Human Swiss Prot No：
• Q9UD71

• Mouse Gene Id：
• 19049

• Mouse Swiss Prot No：
• Q60829

• Rat Gene Id：
• 360616

• Rat Swiss Prot No：
• Q6J4I0

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human DARPP-32 around the phosphorylation site of Thr75. AA range:41-90

• 特异性：
• Phospho-DARPP-32 (T75) Polyclonal Antibody detects endogenous levels of DARPP-32 protein only when phosphorylated at T75.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• PPP1R1B;DARPP32;Protein phosphatase 1 regulatory subunit 1B;DARPP-32;Dopamine- and cAMP-regulated neuronal phosphoprotein

• 实测条带：
• 32kD

• 背景：
• This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],

• 功能：
• function:Inhibitor of protein-phosphatase 1.,PTM:Dopamine- and cyclic AMP-regulated neuronal phosphoprotein.,PTM:Phosphorylation of Thr-34 is required for activity.,similarity:Belongs to the protein phosphatase inhibitor 1 family.,

• 细胞定位：
• Cytoplasm.

• 组织表达：
• Adipose tissue,Brain,Cerebellum,Colon,Ovary,

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