FBL rabbit pAb

  • 货号：YN5902
  • 应用：WB
  • 种属：Human;Mouse;Rat
    • 靶点：
    • FBL
    • 基因名称：
    • FBL FIB1 FLRN
    • 蛋白名称：
    • rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) (34 kDa nucleolar scleroderma antigen)
    • Human Gene Id：
    • 2091
    • Human Swiss Prot No：
    • P22087
    • Mouse Swiss Prot No：
    • P35550
    • 免疫原：
    • Synthesized peptide derived from human FBL
    • 特异性：
    • This antibody detects endogenous levels of FBL at Human, Mouse,Rat
    • 组成：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • 来源：
    • Polyclonal, Rabbit,IgG
    • 稀释：
    • WB 1:500-2000
    • 纯化工艺：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • 浓度：
    • 1 mg/ml
    • 储存：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • 分子量：
    • 35kD
    • 功能：
    • S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins . Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA . Site specificity is provided by a guide RNA that base pairs with the substrate (By similarity). Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Probably catalyzes 2'-O-methylation of U6 snRNAs in box C/D RNP complexes . U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity . Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus .
    • 细胞定位：
    • Nucleus, nucleolus . Nucleus, nucleoplasm . Fibrillar region of the nucleolus.

    相关报价

    • 货号：
    • YN5902
    • 规格：
    • 40μL / 100μL / 200μL
    • 价格：
    • ¥960 / 2300 / 3780
    • 货期：
    • 预计发货时间为
      2024-12-23
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