FUS/TLS rabbit pAb

  • 货号：YN5727
  • 应用：WB
  • 种属：Human;Mouse
    • 靶点：
    • FUS
    • 基因名称：
    • FUS TLS
    • 蛋白名称：
    • RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
    • Human Gene Id：
    • 2521
    • Human Swiss Prot No：
    • P35637
    • Mouse Swiss Prot No：
    • P56959
    • 免疫原：
    • Synthesized peptide derived from human FUS/TLS
    • 特异性：
    • This antibody detects endogenous levels of FUS/TLS at Human, Mouse
    • 组成：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • 来源：
    • Polyclonal, Rabbit,IgG
    • 稀释：
    • WB 1:500-2000
    • 纯化工艺：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • 浓度：
    • 1 mg/ml
    • 储存：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • 分子量：
    • 58kD
    • 功能：
    • DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response . Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing . Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay . Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair . In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity).
    • 细胞定位：
    • Nucleus . Displays a punctate pattern inside the nucleus and is excluded from nucleoli. .
    • 组织表达：
    • Ubiquitous.

    相关报价

    • 货号：
    • YN5727
    • 规格：
    • 40μL / 100μL / 200μL
    • 价格：
    • ¥960 / 2300 / 3780
    • 货期：
    • 预计发货时间为
      2024-11-25
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