• 靶点：
• Kv11.3

• 基因名称：
• KCNH7

• 蛋白名称：
• Potassium voltage-gated channel subfamily H member 7 (Ether-a-go-go-related gene potassium channel 3) (ERG-3) (Eag-related protein 3) (Ether-a-go-go-related protein 3) (hERG-3) (Voltage-gated potassiu

• Human Gene Id：
• 90134

• Human Swiss Prot No：
• Q9NS40

• Mouse Swiss Prot No：
• Q9ER47

• Rat Swiss Prot No：
• O54852

• 免疫原：
• Synthetic Peptide of Kv11.3. AA range 1130-1180

• 特异性：
• Kv11.3 protein(A263) detects endogenous levels of Kv11.3

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:1000-2000, IHC 1:100-200. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Potassium voltage-gated channel subfamily H member 7 (Ether-a-go-go-related gene potassium channel 3;ERG-3;Eag-related protein 3;Ether-a-go-go-related protein 3;hERG-3;Voltage-gated potassium channel subunit Kv11.3)

• 实测条带：
• 83135kD

• 背景：
• Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. There are at least two alternatively spliced transcript variants derived from this gene and encoding distinct isoforms. [provided by RefSeq, Jul 2008],

• 功能：
• domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly.,similarity:Belongs to the potassium channel family. H (Eag) subfamily.,similarity:Contains 1 cyclic nucleotide-binding domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 1 PAS (PER-ARNT-SIM) domain.,subunit:The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH2/ERG1 and KCNH6/ERG2.,tissue specificity:Expressed in prolactin-secreting adenomas.,

• 细胞定位：
• Membrane; Multi-pass membrane protein.

• 组织表达：
• Expressed in prolactin-secreting adenomas.

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