KPYR Polyclonal Antibody

  • 货号：YN2984
  • 应用：WB;ELISA
  • 种属：Human;Mouse;Rat
    • 靶点：
    • KPYR
    • 简介：
    • >>Glycolysis / Gluconeogenesis;>>Pyruvate metabolism;>>Metabolic pathways;>>Carbon metabolism;>>Biosynthesis of amino acids;>>Insulin signaling pathway;>>Type II diabetes mellitus;>>Non-alcoholic fatty liver disease;>>Maturity onset diabetes of the young
    • 基因名称：
    • PKLR PK1 PKL
    • 蛋白名称：
    • Pyruvate kinase isozymes R/L (EC 2.7.1.40) (Pyruvate kinase 1) (R-type/L-type pyruvate kinase) (Red cell/liver pyruvate kinase)
    • Human Gene Id：
    • 5313
    • Human Swiss Prot No：
    • P30613
    • Mouse Swiss Prot No：
    • P53657
    • 免疫原：
    • Synthesized peptide derived from part region of human protein at AA range: 510-550
    • 特异性：
    • KPYR Polyclonal Antibody detects endogenous levels of protein.
    • 组成：
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • 来源：
    • Polyclonal, Rabbit,IgG
    • 稀释：
    • WB 1:500-2000 ELISA 1:5000-20000
    • 纯化工艺：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • 浓度：
    • 1 mg/ml
    • 储存：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • 实测条带：
    • 63kD
    • 背景：
    • The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
    • 功能：
    • catalytic activity:ATP + pyruvate = ADP + phosphoenolpyruvate.,cofactor:Divalent metal cations.,cofactor:Magnesium.,cofactor:Potassium.,disease:Defects in PKLR are a cause of chronic nonspherocytic hemolytic anemia (CNSHA) [MIM:266200]; also called hereditary nonspherocytic hemolytic anemia (HNSHA).,disease:Defects in PKLR are the cause of pyruvate kinase hyperactivity [MIM:102900]; also known as high red cell ATP syndrome. This autosomal dominant phenotype is characterized by increase of red blood cell ATP.,miscellaneous:There are 4 isozymes of pyruvate kinase in mammals: L, R, M1 and M2. L type is major isozyme in the liver, R is found in red cells, M1 is the main form in muscle, heart and brain, and M2 is found in early fetal tissues.,online information:Pyruvate kinase entry,pathway:Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.,similarity:
    • 细胞定位：
    • cytosol,extracellular exosome,
    • 组织表达：
    • Epithelium,Pancreas,

    相关报价

    • 货号：
    • YN2984
    • 规格：
    • 40μL / 100μL / 200μL
    • 价格：
    • ¥960 / 2300 / 3780
    • 货期：
    • 预计发货时间为
      2024-09-02
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