PPM1B Polyclonal Antibody
- 货号：YN2285
- 应用：WB;ELISA
- 种属：Human;Rat;Mouse
- 简介：
- >>MAPK signaling pathway
- 蛋白名称：
- Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta)
- 免疫原：
- Synthesized peptide derived from human protein . at AA range: 310-390
- 特异性：
- PPM1B Polyclonal Antibody detects endogenous levels of protein.
- 组成：
- Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500-2000 ELISA 1:5000-20000
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 背景：
- The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008],
- 功能：
- alternative products:Additional isoforms seem to exist,catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 2 magnesium or manganese ions per subunit.,function:Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro.,similarity:Belongs to the PP2C family.,subunit:Monomer.,tissue specificity:Highly expressed in heart and skeletal muscle.,
- 细胞定位：
- Cytoplasm, cytosol . Membrane ; Lipid-anchor . Weakly associates at the membrane and N-myristoylation mediates the membrane localization. .
- 组织表达：
- Highly expressed in heart and skeletal muscle.
