PA24B Polyclonal Antibody
- 货号:YN0632
- 应用:WB;ELISA
- 种属:Human;Mouse
- 简介:
- >>Glycerophospholipid metabolism;>>Ether lipid metabolism;>>Arachidonic acid metabolism;>>Linoleic acid metabolism;>>alpha-Linolenic acid metabolism;>>Metabolic pathways;>>MAPK signaling pathway;>>Ras signaling pathway;>>Phospholipase D signaling pathway;>>Necroptosis;>>Vascular smooth muscle contraction;>>VEGF signaling pathway;>>Platelet activation;>>Fc epsilon RI signaling pathway;>>Fc gamma R-mediated phagocytosis;>>Glutamatergic synapse;>>Serotonergic synapse;>>Long-term depression;>>Inflammatory mediator regulation of TRP channels;>>GnRH signaling pathway;>>Ovarian steroidogenesis;>>Oxytocin signaling pathway;>>Choline metabolism in cancer
- 蛋白名称:
- Cytosolic phospholipase A2 beta (cPLA2-beta) (EC 3.1.1.4) (Phospholipase A2 group IVB)
- 免疫原:
- Synthesized peptide derived from part region of human protein
- 特异性:
- PA24B Polyclonal Antibody detects endogenous levels of protein.
- 组成:
- Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 稀释:
- WB 1:500-2000 ELISA 1:5000-20000
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 背景:
- This locus represents naturally-occurring readthrough transcription between the neighboring jumonji domain containing 7 (JMJD7) and phospholipase A2, group IVB (cytosolic) (PLA2G4B) genes. Readthrough transcripts encode fusion proteins that share amino acid sequence with each individual gene product, including a partial JmjC domain and downstream C2 and phospholipase A2 domains. Alternatively spliced transcript variants have been observed. [provided by RefSeq, Oct 2013],
- 功能:
- catalytic activity:Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.,caution:Most tissues also express read-through transcripts from this gene into the upstream gene (Jmjd7), some of which may encode fusion proteins.,caution:This sequence was first thought to be an alternatively spliced isoform of Pla2g4b. It is derived from Jmjd7 which is located upstream of Pla2g4b. Most tissues also express read-through transcripts from Jmjd7 into the downstream Pla2g4b gene, some of which may encode fusion proteins combining the N-terminus of this protein with PLA2G4B protein.,domain:The N-terminal C2 domain associates with lipid membranes and mediates its regulation by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).,enzyme regulation:Stimulated by cytosolic Ca(2+).,function:Calcium-dependent phospholipase A2 that selectively hydroly
- 细胞定位:
- [Isoform 3]: Cytoplasm, cytosol . Mitochondrion membrane ; Peripheral membrane protein. Early endosome membrane ; Peripheral membrane protein. Translocates to membrane vesicles in a calcium-dependent fashion. .; [Isoform 5]: Cytoplasm, cytosol .
- 组织表达:
- Widely expressed. Expressed at higher level in brain, heart, liver, cerebellum and pancreas.