• 靶点：
• CD82

• 简介：
• >>p53 signaling pathway

• 基因名称：
• CD82 KAI1 SAR2 ST6 TSPAN27

• 蛋白名称：
• CD82 antigen (C33 antigen) (IA4) (Inducible membrane protein R2) (Metastasis suppressor Kangai-1) (Suppressor of tumorigenicity 6 protein) (Tetraspanin-27) (Tspan-27) (CD antigen CD82)

• Human Gene Id：
• 3732

• Human Swiss Prot No：
• P27701

• Mouse Swiss Prot No：
• P40237

• Rat Swiss Prot No：
• O70352

• 免疫原：
• Synthesized peptide derived from human protein . at AA range: 120-200

• 特异性：
• CD82 Polyclonal Antibody detects endogenous levels of protein.

• 组成：
• Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000 ELISA 1:5000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 实测条带：
• 29kD

• 背景：
• This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

• 功能：
• function:Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.,similarity:Belongs to the tetraspanin (TM4SF) family.,subunit:Interacts directly with IGSF8.,tissue specificity:Lymphoid specific.,

• 细胞定位：
• Cell membrane ; Multi-pass membrane protein .

• 组织表达：
• Lymphoid specific.

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