• 靶点：
• Acrp30

• 简介：
• >>PPAR signaling pathway;>>AMPK signaling pathway;>>Longevity regulating pathway;>>Adipocytokine signaling pathway;>>Type II diabetes mellitus;>>Non-alcoholic fatty liver disease;>>Alcoholic liver disease

• 基因名称：
• ADIPOQ

• 蛋白名称：
• Adiponectin

• Human Gene Id：
• 9370

• Human Swiss Prot No：
• Q15848

• Mouse Gene Id：
• 11450

• Mouse Swiss Prot No：
• Q60994

• 特异性：
• endogenous

• 组成：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• 来源：
• Monoclonal, rabbit, IgG, Kappa

• 稀释：
• IHC 1:1000-1:4000 WB 1:1000-1:5000,IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200,

• 纯化工艺：
• Protein A

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• ADIPOQ;ACDC;ACRP30;APM1;GBP28;Adiponectin;30 kDa adipocyte complement-related protein;Adipocyte complement-related 30 kDa protein;ACRP30;Adipocyte; C1q and collagen domain-containing protein;Adipose most abundant gene transcript 1

• 分子量：
• 26kD

• 实测条带：
• 30kD

• 背景：
• adiponectin, C1Q and collagen domain containing(ADIPOQ) Homo sapiens This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010],

• 功能：
• disease:Defects in ADIPOQ are the cause of adiponectin deficiency (ADPND) [MIM:612556]. ADPND results in very low concentrations of plasma adiponectin.,disease:Genetic variations in ADIPOQ are associated with non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853]; also known as diabetes mellitus type 2. NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance.,domain:The C1q domain is commonly called the globular domain.,function:Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver

• 细胞定位：
• Secreted

• 组织表达：
• Synthesized exclusively by adipocytes and secreted into plasma.

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