Thyroid Peroxidase(TPO) (ABT45R) rabbit mAb
- 货号：YM7277
- 应用：IHC; ELISA
- 种属：Human;
- 简介：
- >>Tyrosine metabolism;>>Metabolic pathways;>>Thyroid hormone synthesis;>>Autoimmune thyroid disease
- 蛋白名称：
- Thyroid Peroxidase(TPO)
- 免疫原：
- Synthesized peptide derived from human Thyroid Peroxidase(TPO) 600-700
- 特异性：
- This antibody detects endogenous levels of Thyroid Peroxidase
- 组成：
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
- 来源：
- Monoclonal, Rabbit IgG1, Kappa
- 稀释：
- IHC 1:100-500, ELISA 1:5000-20000
- 纯化工艺：
- Recombinant Expression and Affinity purified
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 功能：
- alternative products:Additional isoforms seem to exist,catalytic activity:2 iodide + H(2)O(2) + 2 H(+) = 2 iodine + 2 H(2)O.,cofactor:Binds 1 calcium ion per heterodimer.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer.,disease:An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.,disease:Defects in TPO are the cause of congenital hypothyroidism due to dyshormonogenesis type 2A (CHDH2A) [MIM:274500]; also called genetic defect in thyroid hormonogenesis 2A or thyroid hormone organification defect II. CHDH2A is due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.,function:Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).,online information:Thyroid peroxidase entry,pathway:Hormone b
- 细胞定位：
- Membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell surface.
- 组织表达：
- Glandular pool- thyroid,Spleen,Thyroid,
- Immunohistochemical analysis of paraffin-embedded human Follicular thyroid carcinoma. 1, Antibody was incubated at 4° overnight. 2, Citrate buffer of pH6.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
- Immunohistochemical analysis of paraffin-embedded human Thyroid. 1, Antibody was incubated at 4° overnight. 2, Citrate buffer of pH6.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
