Claudin 18 (ABT185R) rabbit mAb
- 货号：YM7264
- 应用：IHC; ELISA
- 种属：Human;
- 简介：
- >>Cell adhesion molecules;>>Tight junction;>>Leukocyte transendothelial migration;>>Pathogenic Escherichia coli infection;>>Hepatitis C
- 免疫原：
- Synthesized peptide derived from human Claudin 18 AA range:150-261
- 特异性：
- This antibody detects endogenous levels of Claudin 18
- 组成：
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
- 来源：
- Monoclonal, Rabbit IgG1, Kappa
- 稀释：
- IHC 1:100-500, ELISA 1:5000-20000
- 纯化工艺：
- Recombinant Expression and Affinity purified
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- Claudin 18;Claudin-18;CLD18_HUMAN;CLDN18;SFTA5;SFTPJ
- 功能：
- function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,tissue specificity:Concentrated at the cell-cell borders of epithelial cells.,
- 细胞定位：
- Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein . Localizes to tight junctions in epithelial cells. .
- 组织表达：
- Isoform A1: Expression is restricted to the lung (PubMed:19047087). Isoform A2: Expression is restricted to the stomach mucosa where it is predominantly observed in the epithelial cells of the pit region and the base of the gastric glands including exocrine and endocrine cells (at protein level) (PubMed:19047087).
- Immunohistochemical analysis of paraffin-embedded human Stomach. 1, Antibody was incubated at 4° overnight. 2, Citrate buffer of pH6.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
