Neurofilament (PT0124R) rabbit mAb
- 货号：YM7175
- 应用：IHC;WB; ELISA
- 种属：Human;
- 简介：
- >>Amyotrophic lateral sclerosis;>>Pathways of neurodegeneration - multiple diseases
- 免疫原：
- Synthesized peptide derived from human Neurofilament AA range:400-543
- 特异性：
- This antibody detects endogenous levels of NF-L
- 组成：
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
- 来源：
- Monoclonal, Rabbit IgG1, Kappa
- 稀释：
- IHC 1:100-500, WB 1:500-1000, ELISA 1:5000-20000
- 纯化工艺：
- Recombinant Expression and Affinity purified
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- 150 kDa medium;160 kDa neurofilament protein;2 kDa neurofilament protein;200 kDa neurofilament protein;68 kDa neurofilament protein;AI847934;CMT1F;CMT2CC;CMT2E;FLJ53642;KIAA0845;light molecular weight neurofilament protein;Micro glutamic acid-rich protein;mKIAA0845;Nef3;NEFH;NEFL;NEFM;Neurofilament 3;Neurofilament heavy polypeptide 200 kDa;Neurofilament heavy polypeptide;Neurofilament light polypeptide 68 kDa;Neurofilament light polypeptide;Neurofilament medium polypeptide 150 kDa;Neurofilament medium polypeptide;Neurofilament protein heavy polypeptide;Neurofilament protein light chain;Neurofilament protein light polypeptide;Neurofilament protein medium polypeptide;neurofilament subunit NF-L;Neurofilament triplet H protein;Neurofilament triplet L protein;Neurofilament triplet M protein;neurofilament-3 (150 kD medium);NF-H;NF-L;NF-M;NF160;NF165;NF200;NF68;NFH;NFL;NFM;NFM_HUMAN;PPP1R110;protein phosphatase 1, regulatory subunit 110
- 背景：
- Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008],
- 功能：
- caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:Defects in NEFL are the cause of Charcot-Marie-Tooth disease type 1F (CMT1F) [MIM:607734]. CMT1F is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT1 group are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. CMT1F is charac
