IRF-4/MUM1 (ABT249R9) rabbit mAb
- 货号：YM7162
- 应用：IHC;WB; ELISA
- 种属：Human;
- 简介：
- >>Th17 cell differentiation
- 免疫原：
- Synthesized peptide derived from human MUM1 AA range:350-451
- 特异性：
- This antibody detects endogenous levels of MUM1
- 组成：
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
- 来源：
- Monoclonal, Rabbit IgG1, Kappa
- 稀释：
- IHC 1:100-500, WB 1:500-1000, ELISA 1:5000-20000
- 纯化工艺：
- Recombinant Expression and Affinity purified
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- Interferon regulatory factor 4;IRF 4;IRF-4;Irf4;IRF4_HUMAN;LSIRF;Lymphocyte specific interferon regulatory factor;Lymphocyte specific IRF;Lymphocyte-specific interferon regulatory factor;Multiple myeloma oncogene 1;MUM 1;MUM1;NF EM5;NF-EM5;NFEM5;PU.1 interaction partner;Sfpi1/PU.1 interaction partner;Transcriptional activator PIP
- 背景：
- The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010],
- 功能：
- disease:A chromosomal aberration involving IRF4 may be a cause of multiple myeloma [MIM:254500]. Translocation t(6;14)(p25;q32) with the IgH locus.,function:Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.,induction:Not induced by interferons.,similarity:Belongs to the IRF family.,similarity:Contains 1 tryptophan pentad repeat DNA-binding domain.,subunit:Interacts with SPIB and DEF6.,tissue specificity:Lymphoid cells.,
