• 靶点：
• GLUT-1

• 简介：
• >>HIF-1 signaling pathway;>>Insulin secretion;>>Thyroid hormone signaling pathway;>>Adipocytokine signaling pathway;>>Glucagon signaling pathway;>>Insulin resistance;>>Bile secretion;>>Human T-cell leukemia virus 1 infection;>>Pathways in cancer;>>Renal cell carcinoma;>>Central carbon metabolism in cancer;>>Diabetic cardiomyopathy

• 基因名称：
• SLC2A1

• 蛋白名称：
• Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) (HepG2 glucose transporter)

• Human Gene Id：
• 6513

• Human Swiss Prot No：
• P11166

• 免疫原：
• Synthesized peptide derived from human GLUT-1 AA range:400-492

• 特异性：
• This antibody detects endogenous levels of GLUT-1

• 组成：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• 来源：
• Monoclonal, Rabbit IgG1, Kappa

• 稀释：
• IHC 1:100-500, ELISA 1:5000-20000

• 纯化工艺：
• Recombinant Expression and Affinity purified

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Choreoathetosis/spasticity episodic (paroxysmal choreoathetosis/spasticity);CSE;DYT17;DYT18;DYT9;EIG12;erythrocyte/brain;Erythrocyte/hepatoma glucose transporter;facilitated glucose transporter member 1;Glucose transporter 1;Glucose transporter type 1;Glucose transporter type 1, erythrocyte/brain;GLUT;GLUT-1;GLUT1;GLUT1DS;GLUTB;GT1;GTG1;Gtg3;GTR1_HUMAN;HepG2 glucose transporter;HTLVR;Human T cell leukemia virus (I and II) receptor;MGC141895;MGC141896;PED;RatGTG1;Receptor for HTLV 1 and HTLV 2;SLC2A1;Solute carrier family 2 (facilitated glucose transporter), member 1;Solute carrier family 2;Solute carrier family 2, facilitated glucose transporter member 1

• 背景：
• This gene encodes a major glucose transporter in the mammalian blood-brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II. Mutations in this gene have been found in a family with paroxysmal exertion-induced dyskinesia. [provided by RefSeq, Apr 2013],

• 功能：
• disease:Defects in SLC2A1 are the cause of autosomal dominant GLUT1 deficiency syndrome [MIM:606777]; also called blood-brain barrier glucose transport defect. This disease causes a defect in glucose transport across the blood-brain barrier. It is characterized by infantile seizures, delayed development, and acquired microcephaly.,disease:Defects in SLC2A1 are the cause of dystonia type 18 (DYT18) [MIM:612126]. DYT18 is an exercise-induced paroxysmal dystonia/dyskinesia. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYT18 is characterized by attacks of involuntary movements triggered by certain stimuli such as sudden movement or prolonged exercise. In some patients involuntary exertion-induced dystonic, choreoathetotic, and ballistic movements may be associated with macrocytic hemolytic anemia.,function:Facilitative g

• 细胞定位：
• Membranous

• 组织表达：
• Detected in erythrocytes (at protein level). Expressed at variable levels in many human tissues.

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