• 靶点：
• CD79A

• 简介：
• >>B cell receptor signaling pathway;>>Primary immunodeficiency

• 基因名称：
• CD79A

• 蛋白名称：
• B-cell antigen receptor complex-associated protein alpha chain (Ig-alpha) (MB-1 membrane glycoprotein) (Membrane-bound immunoglobulin-associated protein) (Surface IgM-associated protein) (CD antigen C

• Human Gene Id：
• 973

• Human Swiss Prot No：
• P11912

• 免疫原：
• Synthesized peptide derived from human CD79a AA range:100-226

• 特异性：
• This antibody detects endogenous levels of CD79A

• 组成：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• 来源：
• Monoclonal, Rabbit IgG1, Kappa

• 稀释：
• IHC 1:100-500, WB 1:500-1000, ELISA 1:5000-20000

• 纯化工艺：
• Recombinant Expression and Affinity purified

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• B lymphocyte-specific MB1 protein;B-cell antigen receptor complex-associated protein alpha chain;CD 79a;CD79a;CD79a antigen (immunoglobulin-associated alpha);CD79A antigen;CD79a molecule, immunoglobulin-associated alpha;CD79A_HUMAN;Ig alpha;Ig-alpha;IGA;IgM-alpha;Immunoglobulin-associated alpha;Ly54;MB-1 membrane glycoprotein;MB1;Membrane-bound immunoglobulin-associated protein;Surface IgM-associated protein

• 分子量：
• 25kD

• 背景：
• The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008],

• 功能：
• disease:Defects in CD79A are a cause of non-Bruton type agammaglobulinemia [MIM:601495]. Agammaglobulinemia is an immunodeficiency disease which results in developmental defects in the maturation pathway of B-cells. Two different mutations, one at the splice donor site of intron 2 and the other at the splice acceptor site for exon 3, have been identified. Both mutations give rise to a truncated protein.,function:Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SY

• 细胞定位：
• Cytoplasmic, Membranous

• 组织表达：
• B-cells.

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